Protein Details: Potassium channel subfamily K member 15

Protein ID

ICDB_Pro_1509

Protein Name

Potassium channel subfamily K member 15

Gene Name

KCNK15; TASK5

Organism

Homo sapiens (Human)

Length

330 amino acids

AlphaFoldDB

AF-Q9H427-F1-model_v4.pdb

Function

Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel.

Sequence

MRRPSVRAAGLVLCTLCYLLVGAAVFDALESEAESGRQRLLVQKRGALRRKFGFSAEDYRELERLALQAEPHRAGRQWKFPGSFYFAITVITTIEYGHAAPGTDSGKVFCMFYALLGIPLTLVTFQSLGERLNAVVRRLLLAAKCCLGLRWTCVSTENLVVAGLLACAATLALGAVAFSHFEGWTFFHAYYYCFITLTTIGFGDFVALQSGEALQRKLPYVAFSFLYILLGLTVIGAFLNLVVLRFLVASADWPERAARTPSPRPPGAPESRGLWLPRRPARSVGSASVFCHVHKLERCARDNLGFSPPSSPGVVRGGQAPRLGARWKSI

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Birk-Barel Syndrome

Location

Detected in pancreas;heart;placenta;lung;liver;kidney;ovary;testis;skeletal muscle and adrenal gland;and at lower levels in prostate;spleen and thyroid gland

DOI ID

10.1006/bbrc.2001.5064; 10.1152/jn.2001.86.1.130; 10.1006/mcne.2001.1045; 10.1007/s004240100620; 10.1038/414865a; 10.1101/gr.2596504

RefSeq

NP_071753.2